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. 2022 May 5;119(19):e2202439119. doi: 10.1073/pnas.2202439119

Fig. 6.

Fig. 6.

Truncated mesothelin (295 to 595 or 295 to 591) and an ascites sample block activity of SS1 CAR T but not 15B6 CAR T. (A and B) OVCAR-8 cells were incubated with 15B6 or SS1 CAR T cells: (A) MSLN (295 to 585) and (B) MSLN (295 to 591). (C and D) KLM-1 cells were incubated with 15B6 or SS1 CAR T cells: (C) MSLN (295 to 585) and (D) MSLN (295 to 591). (E) KLM-1 cells were incubated with 15B6 or SS1 CAR T cells and ascites containing various amounts of MSLN. (F) RH29 cells were incubated with 15B6 or SS1 CAR T cells and ascites containing various amounts of MSLN. After 24 h, cell killing was measured by a luminescent-based cytolytic assay. The concentration on the horizontal axis shows the final concentration of MSLN present in each well.