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. 2022 May 24;13:848961. doi: 10.3389/fimmu.2022.848961

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Copyright © 2022 Wang, Wang, Luu, Chen, Jin, Wang, Huang, Wang, Zhou, Chen, Cui, Li, Tai and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MRN analysis of Metabolomics, Proteomics, and Antibodies. (A) MRN consists of correlation networks using data from antibody, DEPs, and DEMs. Each node is a child network of one data type. The links between nodes were established by weight. (B) The top 10 pathways for metabolite networks correlated with IgG levels at FJ time point. (C) The top 20 pathways for metabolite networks correlated with IgG levels at SJ time point. (D) Connections between IgG, humoral response associated network and metabolite networks at FJ time point are shown. (E) Connections between IgG, humoral response associated network and metabolite networks at SJ time point are shown.