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. 2022 May 24;13:848961. doi: 10.3389/fimmu.2022.848961

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Copyright © 2022 Wang, Wang, Luu, Chen, Jin, Wang, Huang, Wang, Zhou, Chen, Cui, Li, Tai and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of DEMs and their enriched pathways in severe COVID-19 infection, non-Severe COVID-19 infection, FJ and SJ group. (A) Venn diagram showing the number of DEMs from severe COVID-19 vs healthy, non-Severe COVID-19 vs healthy, FJ vs NJ, and SJ vs NJ. (B) Heatmap of the common metabolites shared between CoronaVac immunization and infection. (C) KEGG pathway analysis of DEMs from severe COVID-19 vs healthy. (D) KEGG pathway analysis of DEMs from non-Severe COVID-19 vs healthy. (E) Heatmap of the top KEGG terms enriched from DEMs in severe COVID-19 vs healthy, non-Severe COVID-19 vs healthy, FJ vs NJ and SJ vs NJ. (F) Radar map of the top KEGG terms enriched from DEMs in severe COVID-19 vs healthy, non-Severe COVID-19 vs healthy, FJ vs NJ and SJ vs NJ, respectively. -Log₁₀ p values of KEGG terms were used to make the radar map.