Figure 12.

Summary and future perspectives. (A) Between rat and Xenopus, pre- and post-metamorphosis, there were distinct glycosylation responses to SCI. In the regenerative tadpole, there was a moderate increase in sialylation, a transient increase in GlcNAc in close proximity to the injury, and a continued increase in GlcNAc distant from the injury. (B) Glyco-enzymes of the Golgi could be targeted, ideally in a spatiotemporal manner, to create a more proregenerative environment in the injured spinal cord which, when combined with the structural cues and guidance provided by an aligned collagen hydrogel, should encourage repair of the injured spinal cord. Created with BioRender.com.