Figure 1.

Panel A: Role of the pathway JNK (c- Jun kinase N-terminal) in the first stage of infection with SARS-CoV2: the protein is not explained response (UPR, in the figure); translocates transcription factors such as c- Jun and ATF2 into the nucleus and phosphorylates, dimers to form the activator protein 1 (AP-1) and thus induces the transcription of pro-apoptotic genes such as Bak and FasL; it migrates into the mitochondria where it activates the intrinsic pathway of apoptosis, acting on the Bcl2 family of proteins.

Panel B: Role of the JNK pathway in the advanced stages of infection: emerges through the anti-apoptotic. The switching of this path towards an attitude conducive to cell survival occurs when the infection has become persistent, to use the cell as a source of new viral particles.