The Delingha tree-ring δ18O record (red line) and normalized speleothem δ18O records collected from different parts of continental Asia spanning 5 ka to 3 ka. To place the 4.2-ka event in high-resolution and high-precision context, we constrained our analyses to speleothem records with coverage of 5 ka to 3 ka. A regional composite for southern China is shown, which is derived by averaging the six speleothem δ18O series from Dongge Cave, Xianglong Cave, Wuya Cave, Sanbao Cave 43, Heshang Cave, and Shennong Cave using the Z-score method. Each of the six speleothem records has a temporal resolution better than 20 y, at least five U-Th ages, and dating precision higher than the 60-y average age error (2σ) in the 5- to 3-ka interval. Prior to averaging, each of the six records is first linearly interpolated annually, and then their long-term linear trends in the common period 5 ka to 3 ka are removed to highlight climate fluctuations on multidecadal to centennial timescales before normalization. See ref. 6 for details about each stalagmite record employed in the calculation. The Liu-li Cave in northern China and Kesang Cave (KS06-A-H) in western China speleothem δ18O records are intentionally included for comparison in that both records have a dating point around 4.2 ka (6). The 100-point low-pass filters are shown for Kesang Cave (KS06-A-H), Liu-li Cave, and southern China records. The Shennong Cave and Mawmluh Cave (ML.1) speleothem δ18O records have biannual and subannual resolution, and, therefore, we plot their unsmoothed series for comparison. All horizontal lines represent the long-term average calculated over the common period 5 ka to 3 ka. The vertical dashed blue line indicates the Middle to Late Holocene transition as defined by the Delingha δ18O record via trend-point analysis (2). The gray bar covers the period 3.97 ka to 4.26 ka that is demonstrated as the 4.2-ka event in the midlatitudes of the Northern Hemisphere by the Iranian Gol-E-Zard speleothem record (4).