Table 3B.
Oocyte Cryopreservation Outcomes for All AYA Transmale Cycles.
| Baseline Hormonal Laboratory Values | Median (Range) |
|---|---|
| AMH (ng/ml) | 3.26 (0.44-12.87) |
| FSH (mIU/mL), cycle day 2 | 5.65 (1.7-9.5) |
| E2 (pg/mL), cycle day 2 | 43 (19-163) |
| Stimulation Details | Median (Range) or Percent (Count) |
| Initial FSH Gonadotropin Dose (IU) | 150 (50-300) |
| Initial HMG Gonadotropin Dose (IU) | 75 (0-150) |
| Total Gonadotropin Dose (IU) | 2375 (825-8075) |
| Duration of Stimulation (days) | 10 (8-21) |
| Maximum E2 Level (pg/mL) | 3220 (943-6969) |
| Number of Cancelled Cycles | 5% (1/22) |
| Reason for Cancelled Cycle | Low Response |
| Cycle Protocol | |
| Antagonist | 95% (21/22) |
| Low-dose leuprolide acetate downregulation | 5% (1/22) |
| Trigger Details | |
| 10,000 U hCG only | 9% (2/22) |
| 1000 U hCG + single GnRH-a | 9% (2/22) |
| 1000 U hCG + double GnRH-a | 59% (13/22) |
| 5000 U hCG + double GnRH-a | 14% (3/22) |
| 10,000 U hCG + double GnRH-a | 4.5% (1/22) |
| Post Trigger LH level (mIU/mL) | 82.9 (0.9-187.2) |
| LH < 20mIUm/mL | 15.8% (3/19) |
| LH 20mIUm/mL - 40mIUm/mL | 10.5% (2/19) |
| LH > 40mIUm/mL | 73.7% (14/19) |
| Post Trigger hCG, level (mIU/mL) | 55 (2.66-215) |
| hCG < 40mIU/mL | 47% (9/19) |
| hCG ≥ 40mIU/mL | 53% (10/19) |
| Retrieval Outcomes | Median (Range) or Percent (Count) |
| Total oocytes retrieved, number | 22 (5-59) |
| <10 oocytes retrieved | 14% (3/21) |
| 10-19 oocytes retrieved | 19% (4/21) |
| ≥ 20 oocytes retrieved | 67% (14/21) |
| Maturity Rate | 73% (19%-100%) |
| Number of MII oocyte cryopreserved | 15 (3-35) |
| <10 MII oocytes | 33% (7/21) |
| 10-19 MII oocytes | 43% (9/21) |
| ≥ 20 MII oocytes | 24% (5/21) |
| Number of MI oocyte cryopreserved | 2 (1-9) |
| Any MI cryopreserved | 71% (15/21) |
| Number of GV oocyte cryopreserved | 3 (1-20) |
| Any GV cryopreserved | 81% (17/21) |
AMH, Anti-mullerian hormone.
FSH, Follicle stimulating hormone.
hCG, Human chorionic gonadotropin.
E2, Estradiol level.
HMG, Human menopausal gonadotrophin.
Antagonist, Gonadotropin-releasing hormone antagonist protocol.
Low-dose leuprolide acetate downregulation, Provera for 10 days, leuprolide acetate 10U starting day 6 of provera reducing to 5U on cycle day 2 with initiating of gonadotrophins.
GnRH-a, Gonadotrophin releasing hormone agonist.
LH, Luteinizing hormone.
Total oocytes, Total oocytes (MII, MI, GV).
MII, Metaphase II oocytes.
MI, Metaphase I oocytes.
GV, Germinal Vesicle oocytes.