Table 2.
Comparison of CXCL10, NT‐proBNP, pulmonary hemodynamics, and exercise capacity between baseline and last BPA in CTEPH patients
| Baseline | Last BPA | p | |
|---|---|---|---|
| CXCL10 (pg/ml) | 36.5 (25.0–51.1) | 24.7 (17.2–36.7) | 0.005 |
| 0.0004a | |||
| NT‐proBNP (pg/ml) | 838 (217–2114) | 267 (49–1471) | 0.005 |
| Pulmonary hemodynamics | |||
| Mean RAP (mmHg) | 6 (4–10) | 5 (3–9) | 0.401 |
| Systolic PAP (mmHg) | 80 ± 27 | 68 ± 24 | 0.051 |
| Diastolic PAP (mmHg) | 25 ± 10 | 21 ± 8 | 0.051 |
| Mean PAP (mmHg) | 44 ± 14 | 38 ± 12 | 0.028 |
| PVR (Wood Unit) | 9.8 (7.2–17.1) | 6.7 (4.8–9.9) | 0.005 |
| Cardiac output (L/min) | 3.3 (2.5–4.5) | 4.1 (3.5–5.1) | 0.026 |
| Cardiac index (L/min*m2) | 2.0 (1.6–3.0) | 0.027 | |
| Exercise capacity | |||
| WHO functional class (Ⅰ–Ⅱ/Ⅲ–Ⅳ, %) | 50%/50% | 16%/84% | 0.002 |
| 6MWD (m) | 369 ± 80 | 376 ± 101 | 0.786 |
Note: Data are presented as median and interquartile range or n (%).
Abbreviations: 6MWD, 6 min walk distance; BPA, balloon pulmonary angioplasty; CTEPH, chronic thromboembolic pulmonary hypertension; CXCL10, chemokine (C‐X‐C motif) ligand 10; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; PAP, pulmonary artery pressure; PVR, pulmonary vascular resistance; RAP, right atrium pressure; WHO, World health organization.
a
Wilcoxon matched‐pairs signed‐rank test.