Table 1.

Demographic, disease, imaging and genetic characteristics of pre-FoG and non-FoG subjects at baseline

	Non-FoG (n = 115)	Pre-FoG (n = 68)	P
Demographic information
Age (years)	60.3 [52.8;68.5]	64.9 [56.8;69.6]	0.019*
Age at Symptom Onset (years)	58.6 [50.4;66.3]	62.4 [55.3;68.3]	0.009*
Duration of Disease since Diagnosis (Months)	3.87 [2.33;7.22]	4.82 [2.46;7.02]	0.606
Gender, female	34 (29.6%)	19 (27.9%)	0.948
Years of education	16.0 [14.0;18.0]	16.0 [14.0;18.0]	0.848
Family members with PD (any)	27 (23.5%)	19 (27.9%)	0.620
Disease characteristics
Side most affected at PD onset			0.368
Left	49 (42.6%)	33 (48.5%)
Right	65 (56.5%)	33 (48.5%)
Symmetric	1 (0.87%)	2 (2.94%)
SPECT-DAT
Mean caudate DAT uptake	2.13 (0.49)	1.90 (0.53)	0.005*
Mean putamen DAT uptake	0.86 [0.70;1.03]	0.74 [0.57;0.85]	0.001*
Mean striatum DAT uptake	1.50 (0.35)	1.33 (0.39)	0.003*
CSF biomarkers
Abeta	900 [704;1290]	881 [622;1072]	0.088
Tau	165 [135;210]	159 [140;200]	0.659
pTau	13.6 [11.2;17.2]	13.9 [11.3;17.2]	0.901
aSyn	1462 [1121;1801]	1423 [1141;1724]	0.692
Genetic Pattern
APOE			0.938
e2/e2	1 (0.87%)	0 (0.00%)
e2/e4	4 (3.48%)	1 (1.47%)
e3/e2	13 (11.3%)	10 (14.7%)
e3/e3	68 (59.1%)	40 (58.8%)
e4/e3	26 (22.6%)	16 (23.5%)
e4/e4	3 (2.61%)	1 (1.47%)
SNCA_rs356181			0.414
C/C	38 (33.0%)	20 (29.4%)
C/T	48 (41.7%)	35 (51.5%)
T/T	29 (25.2%)	13 (19.1%)
SNCA_rs3910105			0.427
C/C	20 (17.4%)	8 (11.8%)
C/T	60 (52.2%)	34 (50.0%)
T/T	35 (30.4%)	26 (38.2%)
APOE Genotype—number of e4 alleles	0.31 (0.52)	0.28 (0.48)	0.659
MAPT			1.000
H1/H1	77 (67.0%)	46 (67.6%)
H1/H2	32 (27.8%)	19 (27.9%)
H2/H2	6 (5.22%)	3 (4.41%)

P <0.05 was presented with ‘*’