Table 3.

Meta-analysis of the associations of TLR4Asp299Gly polymorphism with DMI risk

Genetic model	Comparison	Test of association		Test of heterogeneity
		OR (95% CI)	P-value	P	I2 (%)
Dominant model	G/G + A/G vs A/A	1.52 (1.10–2.09)	0.01	0.008	58.0
Allelic model	G vs A	1.42 (1.02–1.96)	0.04	0.003	63.0
Recessive model	G/G vs A/G + A/A	1.87 (0.78–4.46)	0.16	0.94	0.0
Additive model	G/G vs A/A	1.94 (0.81–4.61)	0.14	0.94	0.0
Subgroups
Ethnicity
Caucasians	G/G + A/G vs A/A	1.69 (1.22–2.35)	0.002	0.03	54.0
	G vs A	1.58 (1.10–2.21)	0.01	0.007	62.0
Asians	G/G + A/G vs A/A	0.85 (0.52–1.39)	0.52	0.46	0.0
	G vs A	0.89 (0.56–1.39)	0.60	0.47	0.0
Difference of DMI types
Diabetic retinopathy	G/G + A/G vs A/A	1.81 (1.04–3.14)	0.03	0.004	74.0
	G vs A	1.77 (1.05–2.98)	0.03	0.004	74.0
Diabetic nephropathy	G/G + A/G vs A/A	1.19 (0.81–1.74)	0.38	0.58	0.0
	G vs A	0.91 (0.50–1.64)	0.75	0.24	31.0
Diabetic neuropathy	G/G + A/G vs A/A	1.42 (0.76–2.67)	0.27	0.19	41.0
	G vs A	1.40 (0.80–2.44)	0.24	0.22	34.0

Bold values indicate P-value < 0.05, that is, the combined effect size is statistically significant