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. 2022 Jun 1;42(22):4594–4604. doi: 10.1523/JNEUROSCI.1419-21.2022

Figure 1.

Figure 1.

CREB is inactivated in SN dopaminergic neurons of PD patients. A, B, Sections of human SN obtained from control or PD individuals were immunostained using the p-CREB (A) or CREB antibody (B), respectively, and visualized by DAB staining. Boxed areas are shown at higher magnification in the images below. Scale bars: low magnification, 100 μm; high magnification, 20 μm. C, Adjacent sections of human SN from control or PD individuals were immunostained using the p-CREB or NURR1 antibody, respectively, and visualized by DAB staining. Representative images of p-CREB (top) and NURR1 (bottom) from the same dopaminergic neuron. Scale bar, 20 μm. D, Analysis of the correlation between p-CREB and NURR1 expression in control (n = 3, 133 dopaminergic neurons) and PD (n = 3, 60 dopaminergic neurons) individuals. Pearson correlation coefficient r = 0.4306, p < 0.0001.