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. 2022 Jun 1;42(22):4594–4604. doi: 10.1523/JNEUROSCI.1419-21.2022

Figure 3.

Figure 3.

Increased interaction between CREB and HDAC1 in SN dopaminergic neurons in PD. A, PLA was performed with HDAC1 and CREB in mouse SN dopaminergic neurons (top); n = 4 per group. Scale bars, 10 μm. Quantification of dopaminergic neuron nuclear PLA signal (bottom). B, PLA was performed with HDAC1 and CREB in the human SN dopaminergic neurons (top); n = 4 per group. Scale bars, 10 μm. Quantification of dopaminergic neuron nuclear PLA signal (bottom). Two-way ANOVA (Tukey's): *p < 0.05, **p < 0.01, ****p < 0.0001 versus Saline/Control group; #p < 0.05, ###p < 0.001, ns, not significant as indicated.