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. 2022 Jun 7;20:258. doi: 10.1186/s12967-022-03422-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — miR-18a-5p was downregulated in OC. A Heatmap of significantly downregulated miRNAs in OC microarray GSE161784 (abscissa: sample name; ordinate: miRNA name; small square: the expression level of a miRNA in a sample; upper right histogram: color scale); B Intersection of significantly reduced miRNAs in chemotherapy-resistant samples and miRNAs expressed in hMSC-EVs in the EVmiRNA database was obtained, with the middle as the intersection; C, D Expression of miR-18a-5p was determined by RT-qPCR; E Prognosis of OC patients with low and high miR-18a-5p expression was assessed using Kaplan–Meier survival analysis. Data analysis was performed using one-way ANOVA (panel C) with Tukey's multiple comparisons test for the post hoc test. The independent sample t test was used for comparisons between the two groups (panel D). ***P < 0.001