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. 2022 Jun 6;20:255. doi: 10.1186/s12967-022-03468-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 11 — LAGE1 and Sorafenib regulate tumor growth and lymphatic metastasis in vivo. A Fluorescence imaging of nude mice. B, C Luminescence area and photon flux analysis. D Anatomy of foot-pad primary tumors and metastatic lymph nodes in nude mice. E Measurements of primary tumors and lymph nodes volume. F–H qRT-PCR and WB assay of LAGE1 and lymphangiogenic cytokines. I Immunohistochemical staining for LAGE1 and LYVE-1. Abbreviations: sh-RNA, short hairpin RNA; NC, negative control; (+), addition Sorafinib; (−) without Sorafinib. *P < 0.05, **P < 0.01, ***P < 0.001