Fig. 8. Nucleic acid alkylation using metal carbenes. (a) Structure-selective catalytic alkylation of DNA and RNA (left) and tandem carbene N–H insertion/CuAAC (right) reported by Gillingham. (b) Chemoselective alkylation at guanine O6-G using copper carbenes reported by Gillingham. (c) Site-selective functionalization of oligonucleotides using rhodium carbenes reported by Park, reproduced with permission from ref. 96, licensed under a Creative Commons Attribution (CC BY) license. It is attributed to Park, and the original version can be found here (https://www.nature.com/articles/s41467-021-21839-4).
