Fig. 2.

Blood–brain and blood–CSF barrier integrity in normobilirubinemic and hyperbilirubinemic male and female rats during post-natal development. The integrity of the barriers was assessed by measuring their permeability toward [¹⁴C]-sucrose used as a polar tracer. A Apparent Kin brain measured in 8-h-old animals. B True K_{in brain} measured in 9-day-old animals. C K_{in CSF} measured in 8-h-old (P0) and 9-day-old (P9) animals. Data are expressed as means ± SEM, individual values are shown as open circles. Note that P0 and P9 tissue data are expressed as apparent and true K_in, respectively. See methods for permeability constant definition and calculation