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. 2022 Jun 7;20:261. doi: 10.1186/s12967-022-03458-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Kaplan–Meier curves of patients stratified by three-category I-score, two-category I-score, and two-category I-score and TNM stage. Compared with a low I-score (three-category), a high I-score is associated with superior DFS in discovery cohort (a P = 0.005) and validation cohort (b P = 0.029), whereas an intermediate I-score is not significantly associated with DFS in both cohorts (P > 0.050). Compared with a low I-score (two-category), a high I-score is associated with significantly superior DFS, in both discovery cohort (c P = 0.004) and validation cohort (d P = 0.001). The two-category I-score and TNM stage are significantly associated with DFS in both discovery cohort (e P < 0.001) and validation cohort (f P < 0.001). The unadjusted HRs, corresponding 95% confidence intervals, and P-values are determined by univariable Cox regression models. DFS disease-free survival. HR hazard ratio. Data in parentheses are 95% confidence intervals