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. 2022 Jun 7;20:262. doi: 10.1186/s12967-022-03467-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — TRIM2 is regulated by EPI and participates in the regulation of EMT and CSCs in CRC. A A cluster heatmap of the expression profiles of mRNAs in DMSO- and Epi-treated HCT116 cells. B Ubiquitin-related genes among the differentially expressed genes. C Immunoblot analysis indicated that TRIM2 expression is regulated by EPI. D Western blot analysis revealed that TRIM2 promotes EMT and CSCs in CRC cells. E–G Mammosphere culture analysis revealed that TRIM2 promotes CSCs in CRC cells. H-I Transwell assays revealed that TRIM2 promotes migration in CRC cells. J-K Colony formation assays revealed that TRIM2 promotes proliferation in CRC cells. *P < 0.05, **P < 0.01, ***P < 0.001