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. 2022 Jun 7;20:262. doi: 10.1186/s12967-022-03467-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Stress-induced epinephrine promotes the EMT and transformation of colon cancer cells into cancer stem-like cells through the TRIM2/p53 axis. A–C Western blot analysis indicated that inhibiting TRIM2 expression reverses the EPI-induced promotion of EMT and CSCs in CRC cells. D–F Mammosphere culture analysis revealed that inhibiting TRIM2 expression reverses the effect of EPI on the promotion of CSCs in CRC cells (scale bar: 100 μm). G-H Transwell assays revealed that inhibiting TRIM2 expression reverses the effect of EPI on the promotion of migration in CRC cells. (I-J) Colony formation assays revealed that inhibiting the expression of TRIM2 reverses the effect of EPI on the promotion of proliferation in CRC cells. *P < 0.05, **P < 0.01, ***P < 0.001