Table 3.
Univariable and multivariable analyses for independent variables associated with HCC late recurrence.
| Variables | Univariable cox regression | Multivariable cox regression | ||
|---|---|---|---|---|
| N=133 | HR(95%CI) | P value | HR(95%CI) | P value |
| Age, years | 1.005 (0.972-1.040) | 0.761 | ||
| Gender, (Female vs Male) | 0.472 (0.145-1.536) | 0.212 | ||
| HBsAg, (Yes vs No) | 0.914 (0.401-2.081) | 0.830 | ||
| Cirrhosis, (Yes vs No) | 1.818 (0.834-3.961) | 0.132 | ||
| Neutrophil, 109/L | 0.857 (0.658-1.116) | 0.251 | ||
| Lymphocyte, 109/L | 0.574 (0.287-1.147) | 0.116 | ||
| Platelet, 109/L | 0.994 (0.988-1.000) | 0.038 | 0.999 (0.992-1.006) | 0.760 |
| TBil, μmol/L | 1.017 (0.946-1.093) | 0.655 | ||
| Alb, g/L | 1.004 (0.933-1.081) | 0.914 | ||
| ALT, U/L | 1.004 (0.994-1.013) | 0.456 | ||
| AST, U/L | 0.999 (0.990 1.009) | 0.859 | ||
| PT, s | 1.098 (0.858-1.404) | 0.458 | ||
| AFP, (>400 vs ≤ 400ng/ml) | 0.936 (0.444-1.976) | 0.863 | ||
| Tumor size, cm | 1.016 (0.930-1.110) | 0.723 | ||
| Tumor number, (≥2 vs 1) | 1.575 (0.744-3.335) | 0.235 | ||
| MVI, (Yes vs No) | 0.889 (0.450-1.757) | 0.734 | ||
| Satellitosis | 2.093 (0.733-5.976) | 0.168 | ||
| Splenic volume (mL) | 1.003 (1.001-1.005) | 0.001 | 1.003 (1.001-1.005) | 0.001 |
| BCLC staging | 0.168 | |||
| A | reference | |||
| B | 1.980 (0.862-4.551) | |||
| C | 2.116 (0.634-7.059) | |||
| Differentiation | 0.237 | |||
| well | reference | |||
| moderate | 4.200 (0.574-30.734) | |||
| poor | 2.454 (0.273-22.039) | |||
AFP, alpha fetoprotein; HBsAg, hepatitis be antigen; ALB, albumin; TBIL, total bilirubin; ALT, alanine transaminase; AST, aspartate transaminase; PT, prothrombin time; MVI, microvascular invasion; BCLC, Barcelona Clinic Liver Cancer. ‘P < 0.05’ was highlighted in bold.