Fig. 4.

Analysis of intra- and inter-chain contacts. A, B) Maps of intra- and inter-chain contacts. The points in red, orange and yellow represent frequent, transient and rare contacts, respectively. The points in gray indicate contacts within the folded domains (NTD and CTD) which do not change in the course of the simulations. C) Cartoon representation of a simulation structure with the largest number of contacts. The hydrophobic α-helices (blue) are bound to the NTD (orange) and CTD (red). The IDRs adopt compact conformations. D) Snapshot of a simulation structure with the smallest number of contacts. The hydrophobic α-helices are unbound and the IDRs are rather extended. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)