Fig. 1. PHD3 domain of histone demethylase KDM5A binds histone H3 tail trimethylated at Lys4 (H3K4me3). (A) Domain architecture of KDM5A and oncoprotein NUP98–PHD3. (B and C) Crystal structure of KDM5A-PHD3 (grey) complexed with the H3K4me3 peptide (yellow). PDB 3GL6.7 (D) Solvent-exposed K1620 and K1622 of PHD3 are positioned adjacent to the Q5 residue upon H3K4me3 binding.
