Fig. 2. Structure–activity relationship study of the H3K4me3 10mer peptide. (A) Wild-type histone residues were replaced with Ala in the alanine scan. (B) C-terminal truncation scan. (C) Inhibition constants (Ki) of mutant/truncated H3K4me3 peptides measured using competitive FP assays. Data are represented as average ± three standard errors.
