Table 1.

Follow-up data of the patient with Kleefstra syndrome-2 (KLEFS2) from 9 months to 10 years.

Event	Treatment/testtime	Interventions/test items	Outcomes
Difficult feeding, developmental delay and eczema	9 months to 6 years	Amino acid-based high-energy formula and high-energy high-protein diet	Emaciation and developmental delay were inconspicuously alleviated; Eczema still existed.
	6 to 8 years	High-energy high-protein diet	Emaciation, developmental delay and eczema were not alleviated.
Anemia	9 months to 1 year	Ferrotherapy for 3 months	Anemia was not obviously alleviated. Mild β-thalassemia was diagnosed.
Comprehensive developmental delay	1.58 years	Children's Developmental Center of China (CDCC)	MDI: 63, PDI <50
	3.25 years	Peabody Picture Vocabulary Test (PPVT)	IQ:80 points
	4.75 years	Wechsler Preschool and Primary Scale of Intelligence (WPPSI-II)	FIQ:90 points
	7.1 years	Wechsler Preschool and Primary Scale of Intelligence (WPPSI-II)	FIQ:97 points
	10.5 years	Wechsler Intelligence Scale for Children (WISC-IV Chinese version)	FIQ:87 points
Attention deficit	1.58 years	Neglected by parents.
	5.42 years	Parents were trained about interventions and parenting skills	Attention deficit was improved.
	7.1 to 7.25 years	20 mg/d atomoxetine hydrochloride	Irascibility and impulse behaviors.
	7.25 to 8.1 years	18 mg/d atomoxetine hydrochloride	Hyperactivity symptoms were improved, and attention deficit was not obviously improved. Loss of body weight of 2 kg within 10 months.
	9 to 10 years	1.25 mg/d aripiprazole	Leaving a seat in the classroom was corrected, and impulsive behaviors were improved. Body weight increased by 14 kg per year, especially the gain of abdominal fat.
	10.42 years	18 mg/d methylphenidate hydrochloride	Impulsive behaviors were improved. The body weight was followed up.
Kleefstra syndrome-2	10.42 years	Being followed up

MDI, mental development index; PDI, physical development index; IQ, verbal intelligence quotient; FIQ, full-scale intelligence quotient.