Figure 5.

Hypoxic pregnancy changes placental expression of antiangiogenic factors, increasing the antiangiogenic to proangiogenic balance in maternal plasma. Upper, Values are mean±SEM for the relative placental fold change for sFlt-1 (soluble fms-like tyrosine kinase 1; A), sEng (soluble endoglin; B), and the ratio of sFlt-1 to VEGF (vascular endothelial growth factor; C). Lower, Values are mean±SEM for plasma concentration of sFlt-1 (D) and plasma ratios of sFlt-1 to PlGF (placental growth factor; E) and to VEGF (F). Groups are normoxic (N; ○, n=7–9) and H (●, n=7). Significant differences (P<0.05) are *N vs H or † vs baseline; Student t test for unpaired data or 2-way repeated-measures ANOVA where appropriate. dGA indicates days gestational age.