Table 2.

Pathogenic/likely pathogenic germline variants nor detected by tumor-only sequencing according to biological process

Biological process	Total	Detected	Not detected
			n	%	Lower 95% CI	Upper 95% CI
HRD	633	587	46	7.3	5.5%	9.6%
DDR	289	252	37	12.8	9.4%	17.2%
MMR	245	199	46	18.8	14.4%	24.1%
Other	139	131	8	5.8	3.0%	11.0%
Total	1306	1169	137	10.5	8.9%	12.3%

CI, confidence interval; HRD, homologous recombination deficiency; DDR, DNA damage response; MMR, mismatch repair.