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. 2022 Apr 21;119(17):e2109969119. doi: 10.1073/pnas.2109969119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 6. — Itpr knockdown reduces fast calcium fluctuations. (A–D) As Fig. 1 A–D, (A) raw calcium fluorescence intensity traces from one representative fly with Itpr knockdown in all pacemaker neurons are shown. Each segmented trace is 2-min activity recorded at 1 Hz. Averaged daily patterns of (B) mean calcium intensity, (C) the range of calcium transient, and (D) the power spectrum (n = 5 flies). (E) Bar plots of the daily range of calcium signal for individual neurons of five pacemaker groups between control flies and Itpr knockdown flies. The daily variation of l-LNv, LNd, and DN1 calcium reduces in Itpr knockdown flies (t test). *P < 0.05. (F) Bar plots of SDs of calcium signal in each recording session for individual neurons of five pacemaker groups between control flies and Itpr knockdown flies. The SDs of fast calcium fluctuations in all circadian pacemaker neuron groups are smaller in Itpr knockdown flies than that in control (t test). *P < 0.05.