Fig 12. The potential effect of Stg binding on the structure of full-length Arc.

A Alignment of the extended conformer of the hArc-CTD (orange), crystallised in complex with NbArc-H11 and -C11, and the isolated hArc-CTD N-lobe crystallised in complex with Stg (blue, 6TNO, [34]). NbArc-H11 is shown in transparent orange and the bound Stg in dark blue. The conformational change in the linker region is noted, by arrows pointing towards the NTD. B The hypothesised effect of Stg binding on the structure of linker region and the relative orientation of the two domains of Arc. The linker region is shown in grey.