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. 2022 Jun 7;17(6):e0269646. doi: 10.1371/journal.pone.0269646

Table 5. Functional and behavioural mediators in the association between multimorbidity and depression (Women).

Mediators Indirect effect Direct effect Total effect Mediating %
OR 95% CI P-Value OR 95% CI P-Value OR 95% CI P-Value
Functional health
ADL disability 1.07 [1.06,1.08] <0.001 1.27 [1.17,1.38] <0.001 1.36 [1.25,1.48] <0.001 21.90
IADL disability 1.08 [1.06,1.09] <0.001 1.27 [1.17,1.38] <0.001 1.37 [1.26,1.48] <0.001 23.32
Poor sleep 1.14 [1.11,1.16] <0.001 1.21 [1.11,1.31] <0.001 1.37 [1.26,1.49] <0.001 40.52
Pain 1.03 [1.02,1.04] <0.001 1.32 [1.22,1.43] <0.001 1.36 [1.26,1.48] <0.001 9.96
SRH 1.14 [1.12,1.16] <0.001 1.21 [1.11,1.32] <0.001 1.38 [1.27,1.5] <0.001 40.17
Behavioural health
Currently smoking 1.00 [1,1] 0.90 1.36 [1.25,1.48] <0.001 1.36 [1.25,1.48] <0.001 NA
Alcohol use 1.00 [1,1] 0.18 1.36 [1.25,1.47] <0.001 1.36 [1.25,1.48] <0.001 NA
Physical inactivity 1.02 [1.01,1.02] <0.001 1.38 [1.27,1.49] <0.001 1.40 [1.30,1.52] <0.001 5.17
Obesity 1.00 [0.98,1.01] 0.59 1.38 [1.27,1.5] <0.001 1.38 [1.26,1.5] <0.001 NA

OR: Odds ratio; CI: Confidence Interval; SRH: Self-rated health; ADL: Activities of Daily Living; IADL: Instrumental activities of daily living. Models are adjusted for age, education, place of residence, marital status, caste, religion, and MPCE quintile.