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. 2022 May 17;119(21):e2123000119. doi: 10.1073/pnas.2123000119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Genetic variation at TMPRSS2. (A) Location of coding variants and their MAF at TMPRSS2 identified from the pooled dataset. (B) MAF of coding variants in diverse global ethnic groups. (C) The geographic distribution of the MAF for rs75603675 at TMPRSS2 in diverse global ethnic groups is highlighted. Each pie denotes frequencies of alleles in the corresponding population. (D) Two regulatory eQTLs located in the promoter region of the TMPRSS2 gene. DNase-seq data of the large intestine, small intestine, lung, kidney, and heart are from ENCODE (68).