Fig. 5.

Natural selection signatures at TMPRSS2. (A) The result of the MK test for TMPRSS2 in the pooled dataset. Nonsyn indicates nonsynonymous variants; Syn indicates synonymous variants. “Fixed” denotes variants that were fixed between the human and the chimpanzee; “Poly” represents polymorphic variants within human populations. The transcript ENST00000398585.7 was used for the calculation. (B) Illustration of locations of variants that are divergent between the human and chimpanzee lineages on the TMPRSS2 protein domains. Boxes denote the protein domains of TMPRSS2. Red lines represent nonsynonymous variants that occurred in the corresponding domains of TMPRSS2, with the amino acids and positions of the human and the chimpanzee annotated at the bottom of the lines. Blue lines denote synonymous variants. LDLRA, LDL receptor class A; SRCR, scavenger receptor cysteine-rich domain 2; TM, transmembrane domain.