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. 2022 May 17;119(21):e2120887119. doi: 10.1073/pnas.2120887119

Fig. 2.

Fig. 2.

Epigenetic clocks predict average time to death. (A) LOBO estimates of DNAm average time to death (in years) versus average time to death in years. For each dog, the average time to death was defined as the difference between the median lifespan of the respective breed (LifespanMedian) and chronological age. (B and C) Mean of LOBO DNAm average time to death adjusted for age at breed level versus median lifespan (B) or weight (C). (D) LOBO DNAm average time to death versus chronological age. The association between LOBO DNAm average time to death adjusted for age and the lifespan remains significant (P = 1.5 × 10−10) even after adjusting for average adult weight in a multivariate regression model. (E and F) Phylogenetically independent (Indep.) contrast (PIC)-generated LOBO DNAm average time to death adjusted for age level versus PIC generated lifespan (E) or adult weight (F), at the breed level. For each panel, we report the sample size (n = 742 blood samples or n = 93 dog breeds), Pearson correlation estimate (cor), and Student’s t test P value. Individual dogs are colored by breed as listed in the legend of Fig. 1.