Fig. 1.

Amplitudes of ERG responses to international standard dark-adapted (DA) and light-adapted (LA) stimuli (flash intensities in cd⋅m⁻²⋅s). (A–H) Participants are grouped by number of myopia risk alleles at the locus of interest: Groups 0, 1, and 2 comprise participants with 0, 1, or 2 risk alleles, respectively (gray, blue, and red boxes). Maximal and minimal values are shown as filled black triangles; whiskers denote 5th and 95th centiles; boxes show median and upper and lower quartiles; and opencircles denote mean values. A–E show DA amplitudes and F–H show LA amplitudes. Asterisks denote significance (G and H). (I) Averaged light-adapted flash responses (LA 3 stimulus) for participants with no risk allele (group 0, black traces) and those homozygous for the risk allele (group 2, red traces). Solid and dashed traces show averages of right eye and left eye recordings, respectively. For group 0, the averaged a-waves and b-waves are larger compared with group 2. The blue arrow highlights an inflection or gradient change around 25 ms seen in group 2 traces (and not obviously present in group 0 traces).