Fig. 4.

Retinal expression of GJD2 from two human single-cell transcriptome studies. (A) Data plotted from a supplementary table of a published study from three human donors (26). Eighteen transcriptionally distinct clusters (C0 to C17) were reported. Data plotted here are for GJD2 expression levels in 14 clusters (data for the following clusters are not shown: C15 [horizontal cells] and C16 [astrocytes] had no GJD2 expression; C5 [others] and C14 [others] are also omitted, as the cell type was not identifiable). The C6 (bipolar) cluster was identified as OFF-bipolar cells due to high expression of GRIK1. (B) Retinal schematic highlighting cells expressing GJD2 from another single-cell transcriptome dataset (the Spectacle online resource, accessible at https://singlecell-eye.org/). Expression levels are highest in cones, with significant expression also in rods and bipolar cells. PR, photoreceptor; RGC, retinal ganglion cell; RPE, retinal pigment epithelium.