Table 3.
The features related to mutation probability analyzed for the mutation of concern and mutation of interest.
| Mutation sites of concern/interest | Surface accessibility | Residue bulkiness | Stability of the mutation site | Conservation of the mutation site |
|---|---|---|---|---|
| S:E484 | 1.05 | 68.7 | 3.46 | −0.4 |
| S:L18 | 0.07 | 82.97 | 3.92 | −0.65 |
| S:K417 | 0.64 | 81.13 | 2.94 | −0.25 |
| S:N439 | 0.39 | 68.77 | 4.36 | −0.45 |
| S:L452 | 0.29 | 111.47 | 10.84 | −0.25 |
| S:S477 | 0.96 | 54.13 | 3.82 | −0.35 |
| S:S494 | 0.63 | 86.93 | 8.23 | −0.55 |
| S:N501 | 0.41 | 61.07 | 3.1 | −0.3 |
| S:P681 | 0.61 | 79.2 | 4.6 | −0.85 |
| Average | 0.3 | 82.98 | 5.16 | −0.94 |
Note: The average values are calculated from the mutation sites considered in the current study of SARS-CoV-2 proteome. These mutations of concern/interest are expected to be present at the high mutability sites. The features that do not follow the observed trend in the study are highlighted.
The list of mutations obtained from https://outbreak.info/.
Mutation of concern (MOC): S:E484K.
Mutation of interest (MOI): S:L18F; S:K417N; S:K417T; S:N439K; S:L452R; S:S477N; S:S494P; S:N501Y; S:P681H; S:P681R.