Table 4.
The mutation sites of variants of concern and interest analyzed for four physicochemical features.
| Variant of concern | Mutation sites | Number of features satisfying criteria |
||||
|---|---|---|---|---|---|---|
| 4 | 3 | 2 | 1 | 0 | ||
| Delta (B.1.617.2) | 24 | 11 (45.8%) | 7 (29.2%) | 3 (12.5%) | 2 (8.3%) | 1 (4.2%) |
| Alpha (B.1.1.7) | 19 | 10 (52.6%) | 4 (21.1%) | 5 (26.3%) | 0 (0%) | 0 (0%) |
| Beta (B.1.351) | 16 | 8 (50%) | 4 (25%) | 2 (12.5%) | 2 (12.5%) | 0 (0%) |
| Gamma (P.1) | 22 | 13 (59.1%) | 5 (22.7%) | 3 (13.6%) | 1 (4.5%) | 0 (0%) |
| Variant of interest | ||||||
| Lambda (C.37) | 19 | 7 (36.8%) | 5 (26.3%) | 4 (21.1%) | 3 (15.8%) | 0 (0%) |
| Mu (B.1.621) | 20 | 11 (55%) | 2 (10%) | 6 (30%) | 1 (5%) | 0 (0%) |
As per the study, the satisfactory criteria for the feature is: 1. High mutability sites are likely to have higher than average value for surface accessibility and conservation, and vice versa.
2. High mutability sites are likely to have lower than average value for residue bulkiness, and stability, and vice versa.