Table 2.
Comparison of laboratory results between severe SARS-CoV-2 patients groups.
| All patients (n = 66) | Normal range | Survivors (n = 23) | Non-Survivors (n = 43) | P | Non Mechanical Ventilation (n = 26) | Mechanical Ventilation (n = 40) | P | |
|---|---|---|---|---|---|---|---|---|
| Blood routine | ||||||||
| Mean (range) Hemoglobin (g/dl) | 12.03 (6–19) | 11.5–16 | 12.21 (6–19) | 11.94 (6.4–19) | 0.3155 | 12.35 (10.25–13.75) | 12.07 (6–19) | 0.4348 |
| Mean (range) Red blood cell count (x106/µl) | 4.405 (1.96–6.38) | 4.5–5.6 | 4.38 (2.65–6.38) | 4.27 (1.96–6.38) | 0.4278 | 4.31 (1.96–6.38) | 4.31 (3.69–4.75) | 0.4991 |
| Mean (range) Platelet (x103/µl) | 262.6 (7–621) | 150–450 | 266.9 (23–344) | 260.2 (7–621) | 0.2573 | 243.8 (7–430) | 275.1 (23–621) | 0.2984 |
| Median (IQR) White blood cell count (x103/µl) |
11.5 (9.25–14.5) | 4.5–10 | 10.1 (8.5–13.8) | 11.7 (9.3–14.6) | 0.2235 | 10.2 (8.37–14.1) | 12 (9.32–14.45) | 0.1254 |
| Median (IQR) Lymphocyte count (x103/µl) | 0.7 (0.54–0.93) | 1.125–4 | 0.8 (0.5–1) | 0.7 (0.59–0.9) | 0.353 | 0.7 (0.5–0.94) | 0.7 (0.59–0.94) | 0.2684 |
| Median (IQR) Monocyte count (x103/µl) | 0.42 (0.2–0.65) | 0.09–0.8 | 0.5 (0.2–0.7) | 0.4 (0.2–0.58) | 0.309 | 0.35 (0.2–0.6) | 0.44 (0.3–0.7) | 0.071 |
| Median (IQR) Neutrophil count (x103/µl) | 9.22 (7.82–12.6) | 2.025–7 | 8.8 (6.5–12.6) | 10.18 (8.1–12.85) | 0.086 | 8.7 (6.45–12.77) | 10.09 (8.13–12.73) | 0.2647 |
| Mean (range) Eosinophil count (x103/µl) | 0.0147 (0–0.25) | <0.3 | 0.015 (0–0.18) | 0.0146 (0–0.25) | 0.4523 | 0.01 (0–0.18) | 0.017 (0–0.25) | 0.1211 |
| Mean (range) Basophil count (x103/µl) | 0.0187 (0–0.2) | <0.115 | 0.014 (0–0.1) | 0.02 (0–0.2) | 0.3745 | 0.018 (0–0.2) | 0.018 (0–0.14) | 0.4987 |
| Median (IQR) Neutrophil to lymphocyte ratio (NLR) |
13.61 (9.19–20.56) | 12.86 (7.2–18.11) | 15 (11.51–21.9) | 0.0685 | 15 (9.59–21.6) | 13.6 (8.98–21.6) | 0.4721 | |
| Median (IQR) Lymphocyte to monocyte ratio (LMR) |
1.68 (1.08–2.61) | 1.66 (1.15–2.55) | 1.71 (1.04–3) | 0.3962 | 1.54 (1.07–2.86) | 1.8 (1.11–2.53) | 0.2962 | |
| Coagulation function | ||||||||
| Median (IQR) Troponin (ng/l) | 7.5 (1.5–38) | <1.5 | 6 (1.5–17) | 8 (2–87) | 0.026 | 12.5 (2–22.5) | 5 (1.5–84) | 0.059 |
| Median (IQR) NT-proBNB (pg/ml) | 0.88 (0.05–255) | <300 | 1.25 (0.17–234) | 0.85 (0.13–290.8) | 0.4324 | 1.25 (0.15–382.5) | 0.85 (0.14–215.8) | 0.2724 |
| Mean (range) Fibrinogen (g/l) | 5.92 (1.5–10) | 2–4 | 5.99 (2.7–9.85) | 5.89 (1.5–10) | 0.4781 | 5.47 (1.5–9.65) | 6.23 (2.1–10) | 0.075 |
| Median (IQR) PT (%) | 80 (70–97) | >70 | 86 (69–93) | 80 (70.5–97) | 0.413 | 89.5 (73.5–98) | 79 (67–97) | 0.0807 |
| Median (IQR) INR | 1.13 (1.05–1.2) | 1–1.3 | 1.13 (1.05–1.18) | 1.14 (1.04–1.21) | 0.4881 | 1.08 (1.04–1.18) | 1.14 (1.05–1.23) | 0.1808 |
| Median (IQR) D-dimer (ng/ml) |
2203 (918–3963) | < 500 | 1693 (590–3100) | 2307 (1279–5426) | 0.0257 | 1819 (660–3164) | 2300 (1133–5730) | 0.0198 |
| Infection-related biomarkers | ||||||||
| Median (IQR) Procalcitonin (ng/ml) | 0.29 (0.17–1.28) | <0.05 | 0.16 (0.05–0.59) | 0.33 (0.19–3.69) | 0.0148 | 0.21 (0.07–0.7) | 0.3 (0.17–3.09) | 0.1465 |
| Mean (range) Ferritin (ng/ml) | 1904 (72–13235) | 30–280 | 564.2 (93–934) | 2440 (72–13235) | 0.04 | 1312 (93–7086) | 2348 (72–13235) | <0.0001 |
| Mean (range) C-reactive protein (mg/l) (CRP) | 148.6 (10–441) | <6 | 136.9 (15–320) | 154.9 (10–441) | 0.055 | 146.3 (15–329) | 150.2 (10–441) | 0.4828 |
| Blood biochemistry | ||||||||
| Mean (range) Hematocrit (%) | 36.64 (18.3–57.1) | 36.96 (20–57.1) | 36.47 (18.3–57.1) | 0.4169 | 36.28 (18.3–57.1) | 36.89 (26.5–57.1) | 0.3645 | |
| Mean (range) MCV(fl) | 85 (71.8–103.7) | 84.01 (72–95.2) | 85.56 (71.8–103.7) | 0.3246 | 84.05 (72–95.2) | 85.65 (71.8–103.7) | 0.165 | |
| Mean (range) MCH(pg) | 28.13 (20.4–34.3) | 27.75 (21–31.9) | 28.30 (20.4–34.3) | 0.4534 | 28.24 (21–32.7) | 28.04 (20.4–34.3) | 0.5748 | |
| Mean (range) MCHC (g/dl) | 32.84 (24.4–36.3) | 32.83 (27–36.3) | 32.85 (24.4–35.9) | 0.4798 | 33.05 (27–36.3) | 32.67 (24.4–35.9) | 0.5053 | |
| Mean (range) Reticulocyte (x109/l) | 52.06 (21.8–106) | 54.31 (21.8–106) | 51.18 (23.7–80) | 0.4565 | 47.1 (21.8–86.9) | 54.54 (23.7–106) | 0.1992 | |
Data are presented as mean (range) or median (Interquartile range (IQR)). p values comparing survivors and non-survivors or comparing non-mechanical ventilation and mechanical ventilation severe COVID-19 patients are from Unpaired t-test or the non-parametric Mann-Whitney U test.