Table 4.

Correlation analysis between TIMP1 and related genes and markers of immune cells in TIMER.

Description	Gene markers	GBM
		None		Purity
		Cor	P	Cor	P
CD8+ T cell	CD8A	0.093	0.251	−0.009	0.915
	CD8B	0.168	0.038	0.069	0.420
T cell (general)	CD3D	0.275	∗∗	0.088	0.308
	CD3E	0.266	∗∗	0.121	0.160
	CD2	0.273	∗∗	0.092	0.285
B cell	CD19	0.043	0.600	−0.026	0.760
	CD79 A	−0.037	0.654	−0.087	0.313
Monocyte	CD86	0.313	∗∗∗	0.111	0.198
	CSF1R	0.359	∗∗∗	0.166	0.053
TAM	CCL2	0.579	∗∗∗	0.490	∗∗∗
	CD68	0.406	∗∗∗	0.210	0.014
	IL10	0.397	∗∗∗	0.214	0.012
Macrophage M1	NOS2	0.185	0.022	0.266	∗
	IRF5	0.232	∗	−0.005	0.954
	PTGS2	0.421	∗∗∗	0.330	∗∗∗
Macrophage M2	CD163	0.639	∗∗∗	0.556	∗∗∗
	VSIG4	0.470	∗∗∗	0.316	∗∗
	MS4A4A	0.498	∗∗∗	0.380	∗∗∗
Neutrophils	CEACAM8	−0.049	0.549	−0.086	0.315
	ITGAM	0.447	∗∗∗	0.279	∗∗
	CCR7	0.275	∗∗	0.149	0.081
Natural killer cell	KIR2DL1	−0.007	0.929	−0.037	0.668
	KIR2DL3	−0.020	0.803	−0.083	0.335
	KIR2DL4	0.140	0.083	0.072	0.401
	KIR3DL1	0.036	0.656	0.023	0.793
	KIR3DL2	0.115	0.158	0.115	0.180
	KIR3DL3	0.034	0.675	−0.007	0.935
	KIR2DS4	0.174	0.032	0.136	0.112
Dendritic cell	HLA-DPB1	0.316	∗∗∗	0.175	0.041
	HLA-DQB1	0.241	∗	0.102	0.234
	HLA-DRA	0.339	∗∗∗	0.167	0.051
	HLA-DPA1	0.223	∗	0.100	0.245
Treg	STAT5B	−0.226	∗	−0.132	0.124
	TGFB1	0.411	∗∗∗	0.268	∗

^∗ P < 0.01; ^∗∗P < 0.001; ^∗∗∗P < 0.0001.