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. 2022 May 26;23(6):878–891. doi: 10.1038/s41590-022-01208-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Field excitatory post-synaptic potentials (fEPSPs) were recorded from Schaffer collateral-CA1 neuronal synapses in brain slices from wildtype and αCamKII^IL-2 littermates. Input-output curves were recorded for each slice by applying single-stimuli ranging from 500 to 2750 mV with 250 mV increments. a Slope and b amplitude were analyzed (n = 4,4). Long-term potentiation (LTP) was induced by applying three high frequency trains (theta-burst stimulation (TBS): 100 stimuli; 100 Hz) with 5 minutes intervals between trains. After baseline determination, fEPSPs were measured for 55 minutes. Changes in the c slope and d amplitude have been analyzed across time. Boxplots represent quantification of the baseline (left) (Amplitude: Minimum (0, 02845), 25% Percentile, (0.2020, 0.3137), Median (0.3471, 0.4084), 75% Percentile (0.6997, 0.6627), Maximum (1.203, 0.7302); Slope: Minimum (0.06911, 0.08740), 25% Percentile (0.08134, 0.1182), Median (0.2409, 0.1463), 75% Percentile (0.3236, 0.2653), Maximum (0.4574, 0.2747) and final LTP (right) (Amplitude: Minimum (132.1, 130), 25% Percentile (132.4, 130.8), Median (152.7, 145.7), 75% Percentile (176.5, 191.1), Maximum (177.9, 202); Slope: Minimum (138.2, 131.3), 25% Percentile (138.7, 134.4), Median (151.3, 150.3), 75% Percentile (170.3, 191.6), Maximum (173.0, 203.2)). Mean ± s.e.m. (n = 4,4). Statistical analyses were performed using unpaired, nonparametric Mann–Whitney U-test.

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