Table 2. Regression analyses on maximal and mean intima-media thickness (IMT) of the carotid arteries and Achilles tendon thickness (mm) in relation to lipid and clinical parameters at baseline.
| Parameter | Unit in change or comparison | n | Regression coefficient＊ | Robust SE | P-value | Standardized regression coefficient† |
|---|---|---|---|---|---|---|
| Maximal IMT (mm) | ||||||
| LDL cholesterol | Per 10 mg/dL | 495 | 0.015 | 0.007 | 0.04 | 0.072 |
| HDL cholesterol | Per 10 mg/dL | 510 | -0.098 | 0.024 | ＜10－4 | -0.200 |
| HDL cholesterol‡ | Per 10 mg/dL | 412 | -0.045 | 0.027 | 0.10 | -0.090 |
| Triglycerides | Per ln (mg/dL) | 511 | -0.059 | 0.060 | 0.32 | -0.037 |
| RLP-C | Per ln (mg/dL) | 304 | 0.037 | 0.052 | 0.48 | 0.028 |
| Lp(a) | Per ln (mg/dL) | 359 | 0.035 | 0.038 | 0.36 | 0.037 |
| Rf | Per 0.10 | 151 | 0.074 | 0.146 | 0.61 | 0.043 |
| Body mass index | Per kg/m2 | 491 | -0.011 | 0.009 | 0.18 | -0.049 |
| CAD | (+) vs. (−) | 115/396 | 0.345 | 0.093 | ＜10－3 | 0.170 |
| Cerebral infarction | (+) vs. (−) | 17/494 | 0.263 | 0.185 | 0.16 | 0.056 |
| Hypertension | (+) vs. (−) | 153/358 | 0.250 | 0.083 | 0.003 | 0.135 |
| Diabetes mellitus | (+) vs. (−) | 91/420 | 0.123 | 0.093 | 0.19 | 0.055 |
| Smoking | Past vs. never | 95/363 | 0.134 | 0.091 | 0.14 | 0.062 |
| Current vs. never | 41/363 | 0.226 | 0.121 | 0.06 | 0.074 | |
| Mean IMT (mm) | ||||||
| LDL cholesterol | Per 10 mg/dL | 444 | 0.009 | 0.003 | 0.002 | 0.114 |
| HDL cholesterol | Per 10 mg/dL | 458 | -0.040 | 0.008 | ＜10－6 | -0.212 |
| HDL cholesterol‡ | Per 10 mg/dL | 370 | -0.029 | 0.009 | 0.001 | -0.156 |
| Triglycerides | Per ln (mg/dL) | 459 | -0.056 | 0.023 | 0.02 | -0.090 |
| RLP-C | Per ln (mg/dL) | 271 | -0.005 | 0.020 | 0.82 | -0.010 |
| Lp(a) | Per ln (mg/dL) | 324 | 0.020 | 0.017 | 0.24 | 0.056 |
| Rf | Per 0.10 | 128 | 0.052 | 0.053 | 0.32 | 0.073 |
| Body mass index | Per kg/m2 | 445 | 0.002 | 0.003 | 0.54 | 0.021 |
| CAD | (+) vs. (−) | 102/357 | 0.125 | 0.039 | 0.001 | 0.155 |
| Cerebral infarction | (+) vs. (−) | 14/445 | 0.078 | 0.072 | 0.28 | 0.040 |
| Hypertension | (+) vs. (−) | 135/324 | 0.076 | 0.035 | 0.03 | 0.103 |
| Diabetes mellitus | (+) vs. (−) | 79/380 | 0.017 | 0.037 | 0.65 | 0.019 |
| Smoking | Past vs. never | 89/325 | 0.048 | 0.038 | 0.20 | 0.059 |
| Current vs. never | 37/325 | 0.037 | 0.045 | 0.41 | 0.031 | |
| Achilles tendon thickness (mm) | ||||||
| LDL cholesterol | Per 10 mg/dL | 470 | 0.134 | 0.046 | 0.004 | 0.139 |
| HDL cholesterol | Per 10 mg/dL | 484 | -0.386 | 0.101 | ＜10－3 | -0.163 |
| HDL cholesterol‡ | Per 10 mg/dL | 388 | -0.372 | 0.119 | 0.002 | -0.145 |
| Triglycerides | Per ln (mg/dL) | 485 | -0.223 | 0.429 | 0.60 | -0.028 |
| RLP-C | Per ln (mg/dL) | 296 | -0.137 | 0.394 | 0.73 | -0.021 |
| Lp(a) | Per ln (mg/dL) | 347 | 0.262 | 0.222 | 0.24 | 0.060 |
| Rf | per 0.10 | 142 | 2.233 | 1.067 | 0.04 | 0.236 |
| Body mass index | Per kg/m2 | 466 | -0.015 | 0.050 | 0.76 | -0.013 |
| CAD | (+) vs. (−) | 112/374 | 1.893 | 0.498 | ＜10－3 | 0.193 |
| Cerebral infarction | (+) vs. (−) | 14/472 | 0.222 | 0.949 | 0.81 | 0.009 |
| Hypertension | (+) vs. (−) | 153/333 | 0.310 | 0.451 | 0.49 | 0.035 |
| Diabetes mellitus | (+) vs. (−) | 86/400 | 0.682 | 0.554 | 0.22 | 0.063 |
| Smoking | Past vs. never | 95/342 | 1.306 | 0.551 | 0.02 | 0.127 |
| Current vs. never | 38/342 | 0.827 | 0.773 | 0.29 | 0.055 |
＊Adjusted for sex and age. †Regression coefficient divided by standard deviation of the parameter of study.
‡Excluding probucol users.