Table 3.
Risk of colorectal adenomas and cancer incidence from E-DII from food and supplement stratified by family history of colorectal cancer and age.
| E-DII Tertilesa | Pinteractiond | |||
|---|---|---|---|---|
| T1 | T2 | T3 | ||
| Incident adenoma | ||||
| No family history of colorectal cancer (N) | 340 | 339 | 346 | 0.32 |
| Multivariable-adjusted HR (95% CI)b | Reference | 0.97 (0.83, 1.13) | 0.95 (0.79, 1.13) | |
| Have a family history of colorectal cancer (N) | 38 | 38 | 45 | |
| Multivariable-adjusted HR (95% CI)b | Reference | 0.62 (0.37, 1.04) | 0.80 (0.46, 1.39) | |
| Recurrent adenoma | ||||
| No family history of colorectal cancer (N) | 202 | 254 | 278 | 0.66 |
| Multivariable-adjusted HR (95% CI)b | Reference | 1.11 (0.92, 1.35) | 1.05 (0.85, 1.30) | |
| Have a family history of colorectal cancer (N) | 34 | 37 | 43 | |
| Multivariable-adjusted HR (95% CI)b | Reference | 1.22 (0.74, 1.99) | 0.99 (0.58, 1.68) | |
| Colorectal cancer | ||||
| Age ≤65, years | 130 | 154 | 180 | 0.16 |
| Multivariable-adjusted HR (95% CI)c | Reference | 1.11 (0.85, 1.45) | 1.59 (1.21, 2.08) | |
| Age >65, years | 114 | 116 | 127 | |
| Multivariable-adjusted HR (95% CI)c | Reference | 1.09 (0.67, 1.20) | 1.20 (0.99, 1.45) | |
aThe E-DII tertiles are as follows: for analyses on incident adenoma and recurrent adenoma, T1: −7.10 to −1.37, T2: −1.36 to 1.10, T3: 1.11 to 7.27; for analysis on colorectal cancer, T1: −8.63 to −5.00, T2: −4.99 to −2.92, T3: −2.91 to 5.81.
bAdjusted for age (continuous), gender (male, female), body mass index (continuous), smoking status (current, former, never), alcohol drinking status (current, former, never), marital status (single, married, divorced or separated, widowed), educational level (less than high school, high school graduate or equivalent, post-high school education, college education or higher), physical activity (active less than one time per month, active at least one time per month), and Non-steroidal anti-inflammatory drugs use status (yes, no).
cAdjusted for gender (male, female), body mass index (continuous), smoking status (current, former, never), alcohol drinking status (current, former, never), marital status (single, married, divorced or separated, widowed), educational level (less than high school, high school graduate or equivalent, post-high school education, college education or higher), physical activity (active less than one time per month, active at least one time per month), family history of colorectal cancer (yes, no), and non-steroidal anti-inflammatory drugs use status (yes, no).
dPinteraction was calculated by adding the cross-product of quintile E-DII in the multivariable-adjusted Cox regression model.