Table 3.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) of gastric cancer for the highest compared to the lowest study-specific tertile of allium vegetables intake in strata of selected variables in the Stomach cancer Pooling (StoP) Project consortium.
| Cases/controls (number of included studies) | OR (95% CI) | I2 (%) | |
|---|---|---|---|
| Area | |||
| Europe | 3422/8389 (8) | 0.96 (0.81–1.13) | 38.3 |
| Asia | 1839/2660 (6) | 0.50 (0.29–0.86) | 89.5 |
| The Americas | 836/1968 (3) | 0.66 (0.39–1.11) | 78.7 |
| p-value heterogeneity = 0.042 | |||
| Sex | |||
| Men | 3870/7423 (17) | 0.71 (0.56–0.90) | 73.9 |
| Women | 2227/5594 (17) | 0.76 (0.58–1.01) | 63.2 |
| p-value heterogeneity = 0.700 | |||
| Age (years) | |||
| <60 | 2220/5256 (17) | 0.74 (0.57–0.95) | 61.0 |
| ≥60 | 3877/7761 (17) | 0.70 (0.54–0.91) | 77.5 |
| p-value heterogeneity = 0.79 | |||
| Socioeconomic status | |||
| Low-intermediate | 3680/6311 (17) | 0.72 (0.54–0.96) | 77.9 |
| High | 2373/6640 (17) | 0.73 (0.58–0.92) | 581 |
| p-value heterogeneity = 0.933 | |||
| Smoking habit | |||
| Never-former | 4376/9798 (17) | 0.73 (0.59–0.91) | 73.1 |
| Smoker | 1721/3219 (17) | 0.67 (0.48–0.94) | 66.3 |
| p-value heterogeneity = 0.690 | |||
| Alcohol drinking (g/day) | |||
| Never-low (≤12) | 2498/7112 (15) | 0.74 (0.57–0.96) | 71.3 |
| Intermediate (>12–47)–High (>47) | 2427/4020 (12) | 0.93 (0.80–1.10) | 7.4 |
| p-value heterogeneity = 0.136 | |||
| History of gastric cancer in first degree relatives | |||
| No | 2871/7410 (12) | 0.71 (0.50–1.00) | 84.4 |
| Yes | 718/691 (11) | 1.01 (0.73–1.40) | 0.0 |
| p-value heterogeneity = 0.138 | |||
| Total fruit and vegetable intakea | |||
| Low-Intermediate | 3824/7520 (16) | 0.73 (0.56–0.95) | 76.2 |
| High | 2003/4598 (17) | 0.68 (0.49–0.94) | 75.1 |
| p-value heterogeneity = 0.701 | |||
| Type of controls | |||
| Hospital-based | 1978/3287 (7) | 0.82 (0.67–1.00) | 36.3 |
| Population-based | 4119/9730 (10) | 0.64 (0.45–0.91) | 88.9 |
| p-value heterogeneity = 0.237 | |||
| HP infection | |||
| Seronegative | 668/1378 (8) | 0.66 (0.43–0.99) | 43.1 |
| Seropositive | 1738/4588 (9) | 0.57 (0.32–1.03) | 89.8 |
| p-value heterogeneity = 0.716 | |||
| Histological typeb | (9) | ||
| Intestinal | 1689/9315 | 0.74 (0.48–1.14) | 84.6 |
| Diffuse | 989/9315 | 0.80 (0.56–1.14) | 67.0 |
| Unspecified | 846/9315 | 0.60 (0.39–0.94) | 72.5 |
| p-value heterogeneity = 0.628 | |||
| Siteb | (12) | ||
| Cardia | 613/10196 | 0.73 (0.42–1.27) | 77.6 |
| Non-cardia | 3158/10196 | 0.67 (0.47–0.97) | 86.4 |
| p-value heterogeneity = 0.808 | |||
HP Helicobacter pylori.
aStudy-specific tertiles.
bAnalysed using multinomial multivariable logistic model.