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. 2022 Feb 22;126(12):1824–1833. doi: 10.1038/s41416-022-01742-5

Fig. 1. Molecular analysis of colorectal peritoneal metastases reveals multiple features of aggressive tumour behaviour.

Fig. 1

a RNA sequencing of PM (n = 59) and paired primary tumour regions (n = 35) from 12 individual patients was performed. The t-SNE plot shows the clustering of most samples per patient. b The same t-SNE plot colour coded by site (primary versus PM). c Gene set enrichment analyses of all Hallmark signatures (n = 50) and immune cell gene sets (Bindea and Cell-ID). All gene sets that were significantly enriched in either PM or primary tumour samples are shown and ordered by the significance and direction of enrichment. d Examples of box plots of individual gene sets expressed at significantly different levels in either PM or primary tumour samples.