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. 2022 Feb 25;126(12):1795–1805. doi: 10.1038/s41416-022-01744-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The RSD distribution of QC samples. b Protein expression profile of PC9-BrM3 compared to parent PC9. c Volcano plot shows the upregulation of candidate proteins. d Results of enzyme-linked immunosorbent assay (ELISA) showing serum levels of ten candidate proteins in each clinical group in cohort 1. Results of ELISA showing serum levels of Cathepsin F (CTSF) (e), Fibulin-1 (FBLN1) (f) and Aldo-keto reductase family 1 member B10 (AKR1B10) (g) in each clinical group in cohort 2. Each dot corresponds to a single individual. Data are presented as mean ± SD; ***P < 0.001; **P < 0.01; *P < 0.05. LCBM non-small cell lung cancer (NSCLC) brain metastasis (BM), LM single organ liver metastasis, BoM single organ bone metastasis, ALC advanced NSCLC without distant organ metastasis, ELC early-stage NSCLC, PBT primary brain tumours, HG healthy group. The graphs show summarised results from three independent experiments.