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. 2022 Jun 7;13:3272. doi: 10.1038/s41467-022-30899-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Structural comparison of AB_closed to mEAK7 bound AB_semi. b Structural comparison of AB_open to mEAK7 bound AB_semi. c The cartoon model explains the uniqueness of the mEAK7 binding site. d–f The conformational changes of V-ATPase compared to apo bovine V-ATPase. g–i The conformational changes of V-ATPase compared to SidK-bound human V-ATPase. All conformational changes are indicated by either a red oval or arrows.