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. 2022 Jun 7;12:9380. doi: 10.1038/s41598-022-13233-x

Table 4.

Uncertainty of the proposed model and available correlations in the literature in terms of AARD% (the italicized cells are calculated in the current study; the bold font values show the most accurate predictions).

Drug Empirical correlation
Modified Arrhenius Chrastil35 Jouyban et al.36 Kumar and Johnston37 Garlapati and Madras38
Sorafenib tosylate 7.91 13.9019 14.4019 12.7019 11.0019
Sunitinib malate 3.89 21.2620 14.2020 38.85 17.1620
Azathioprine 4.29 9.8821 10.2121 16.26 8.6221
Busulfan 7.41 11.2022 88.70 7.5722 11.2022
Tamoxifen 12.02 16.5023 96.87 11.1023 16.4023
Letrozole 13.21 22.16 21.5024 39.42 7.1424
Tamsulosin 9.27 22.1125 82.70 15.2025 24.91
Capecitabine 11.42 12.2026 11.9026 10.3026 43.48
Paclitaxel 9.69 28.90 80.95 38.89 11.79
5-Fluorouracil 8.39 19.48 69.90 19.48 22.77
Thymidine 16.64 25.10 91.77 29.86 32.48
Decitabine 9.11 15.3028 88.88 9.0428 15.3028
Overall 9.54 17.42 56.51 18.97 19.64
Drug Empirical correlation
Bian et al.39 Bartle et al.40 MST41 Sodeifian et al.42 Tan et al.43 Gordillo44
Sorafenib tosylate 10.3019 13.7019 15.3019 10.1019 52.21 95.85
Sunitinib malate 21.0720 26.1120 24.6820 12.1620 54.69 91.67
Azathioprine 8.4021 12.2221 10.7021 8.0421 13.72 84.91
Busulfan 6.55 11.7022 10.7022 25.99 32.48 96.87
Tamoxifen 8.84 16.1023 16.0023 58.03 45.91 96.87
Letrozole 10.42 46.61 15.4024 26.66 39.20 95.00
Tamsulosin 14.2425 17.0825 16.9825 13.6425 29.07 95.83
Capecitabine 33.00 12.8026 9.9026 41.4726 9.1026 20.5026
Paclitaxel 15.96 50.09 55.31 9.26 18.44 95.23
5-Fluorouracil 15.59 35.34 31.98 13.86 25.52 82.99
Thymidine 19.68 46.90 40.32 22.31 32.78 96.00
Decitabine 8.82 15.3028 13.3028 80.01 49.18 96.88
Overall 14.90 23.24 20.01 30.05 33.19 84.66