Glucagon-like peptide 1 receptor agonists (GLP1RAs) have recently gained momentum after the introduction of semaglutide, the first oral molecule in their class.

This manuscript describes the value and positioning of oral semaglutide in common clinical situations. Specific tips on how to prescribe this drug in a large spectrum of people living with type 2 diabetes are mentioned.

The utility of oral semaglutide in those using injectable GLP-1RA formulations, those having sudden changes in their life style pattern due to religious, social, or professional commitments, those seeking help for urgent glycemic control, or those experiencing a sudden change in their concomitant medications or comorbidities is explained.