Meta-analysis of 75 observational studies confirms that using the FreeStyle Libre system is associated with a significant reduction in HbA1c for adults and children with type 1 diabetes (T1DM) and for adults with type 2 diabetes (T2DM).

Reductions in HbA1c associated with using the FreeStyle Libre system are sustained for 24 months for adults and children with T1DM and for at least 12 months for adults with T2DM, indicating that the fall in HbA1c is a consequence of using the FreeStyle Libre system rather than transient confounding factors around the time of initiation.

Both in T1DM and in T2DM, the degree of change in HbA1c is predicted by the HbA1c at baseline, such that a greater reduction in HbA1c is seen for users with a higher baseline HbA1c.

The observed patterns of change in HbA1c in T1DM and T2DM across 75 studies are not different after starting the FreeStyle Libre system, indicating that flash glucose monitoring can be used in the same way to reduce long-term glucose exposure for adults with either T1DM or T2DM.