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. 2022 Jun 8;40(32):4609–4616. doi: 10.1016/j.vaccine.2022.06.020

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© 2022 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 3 — Clinical characteristics, reproductive performance, virus replication, antibody detection and histopathological characteristics in hACE2 pregnant mice infected with SARS-CoV-2. (A) Experimental design and sample collection. Thirteen mice were used in this study. Eight pregnant mice (M/CV group, n = 8) were inoculated with CoronaVac and challenged intranasally with SARS-CoV-2 at 100 TCID₅₀. The control group (M/CM group, n = 5) were infected intranasally with the same dose of SARS-CoV-2. (B) Infected pregnant mice were observed for changes in body weight and percent survival at the indicated time points. (C) Reproductive performance indices. (D) The viral RNA loads of pregnant mice were quantified by RT-PCR at 5dpi; the titers of S1-specific IgG and NAb in hACE2 pregnant mice were also tested. (E) Histopathological characteristics of pregnant mice at 5 dpi were analyzed.