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. 2022 Jun 7;12:9400. doi: 10.1038/s41598-022-13488-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression of ECS genes in endometrium across the menstrual cycle. (A) Using 206 endometrial samples we found that of the 70 genes identified through the literature to function as part of ECS, 40 were expressed in at least 90% of the samples. The level of expression of each gene varied significantly between individuals and mean expression varied between genes. (B) A heat map analysis identifying the relative expression (cpm) of each gene across the menstrual cycle. The stage variation identified for some of these genes could be explained in part by differences that occurred in expression across the menstrual cycle. M = Menstrual, EP = Early proliferative, MP = Mid proliferative, LP = Late proliferative, ES = Early secretory, MS = Mid secretory, LS = Late secretory.